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The Macintosh is Year 2000 compliant, but Windows and Unix machines, particularly older models, are vulnerable. And any applications that cannot handle the date change properly must be revised, regardless of the platform they are running on. Our own systems are the least of our worries, however. Even if they are compliant, we still have to worry about the computers running the rest of our world.

Important dates: January 1, 2000 and beyond

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Bupropion 300 mg and weight loss. In this study, patients took 400 mg and 800 once daily with meals and did not take bupropion during meals. Two patients dropped out due to adverse events [1]. The median adherence to treatment regimen was 96%. The most common side effects were headache (5%), back pain (3%), and diarrhea (1%). In a study of bupropion patients taking antidepressant medications, the bupropion hcl sr and weight loss use of bupropion led to a statistically significant decrease in depression scores compared to a placebo (38.3% vs 38.3% [3], p<.05) [4]. Furthermore, a meta-analysis of clinical trials bupropion hcl sr for weight loss showed that bupropion did not alter plasma levels of serotonin (5-hydroxytryptamine, 5HT), norepinephrine (NE), nor dopamine (DA) [5]. A recent meta-analysis of six bupropion studies suggested that a daily dose of 200 mg/day for eight weeks was not effective for symptom relief by patients with major depression, compared placebo (38.0% vs 42.6% [6]). A smaller clinical trial comparing placebo and bupropion plus venlafaxine for 12 weeks, showed a slight reduction in symptoms with an enhanced reduction in depressive symptoms. Results of these studies were largely consistent among those who received only placebo or bupropion, suggesting that bupropion may be effective for patients with depression at an earlier stage of illness. The use of a non–active agent and the choice of dose might impact efficacy. In a randomized, double-blind, placebo-controlled trial of bupropion versus placebo in 12 patients with major depression, only one participant received a higher dose of bupropions from the beginning treatment (n=6; 300 mg twice daily) [7]. This lack of placebo effect may indicate that the dose of 300 mg twice daily might have been too high in this case. However, it would not have been unreasonable to begin with a daily dose of 200 mg and gradually increase the dose over a period of four weeks, until bupropion's efficacy was maximal. Because it is unlikely to produce significant side effects, bupropion has the most favourable safety profile of current antidepressants. However, some side effects, such as dizziness, dry mouth, drowsiness, and nausea are likely to continue occur, because no drug directly stimulates CNS receptors. In the absence of a drug, placebo responses must be considered. If patients are not motivated to self-medicate effectively, their antidepressant response may remain at risk, because they may not seek treatment if they feel using bupropion for weight loss the antidepressant may be a placebo [8]. The potential adverse effects of bupropion such as nausea and dizziness are less likely to require a medication suppress these symptoms, because the drug does not change sensation. However, patients with gastrointestinal disorders should not start bupropion without consultation with a healthcare practitioner, who can determine if a dose of 300 mg is appropriate. Bupropion is considered relatively safe for the elderly. It does not appear to increase the risk of breast cancer, pancreatic and kidney stones [4]. More research is therefore required to establish whether bupropion is safe for patients at risk these specific events. Bupropion: clinical trials assessing efficacy for mild to moderate depression A number of trials have assessed the effectiveness of bupropion for patients with mild or moderate depression. Bupropion (Everest) In a placebo-controlled trial patients with major depression, received 150 mg of bupropion once monthly throughout the study. In treatment group, which took bupropion three times daily, there were no differences in outcome measures the two groups. main risk-reducing effect was seen in those patients who had been on a mood stabilizer for more than six months. The proportion of patients that were prescribed.

  1. Ravenna
  2. Hammond
  3. Hebron
  4. Elmo
  5. Kersey


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Bupropion is used for treating depression.

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